SCHEMBL5683196

SCHEMBL5683196

CCCn1cc(C2=C(c3cn(C)c4ccccc34)C(=O)NC2=O)c2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CCNE2 O96020 2/20 0.76
CDK4 P11802 2/20 0.76
CCND1 P24385 2/20 0.76
CCNE1 P24864 2/20 0.76
CDK2 P24941 2/20 0.76
PIM1 P11309 2/20 0.76
CAMK2D Q13557 1/20 0.76
PRKCA P17252 1/20 0.72
PRKACA P17612 1/20 0.72
PRKACG P22612 1/20 0.72
PRKACB P22694 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30319841 1.00 CCNE2 (0.76) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL8161322 0.88 CCNE2 (0.74) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL28912765 0.88 CCNE2 (0.74) CCNE2CDK4CCND1CCNE1CDK2
Hydrochloric Acid SCHEMBL8163206 0.88 PIM1 (0.86) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL30319849 0.87 CCNE2 (1.00) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL5686048 0.87 CCNE2 (1.00) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL8162785 0.86 PIM1 (0.79) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL8122815 0.86 PRKCA (0.87) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL8161666 0.86 PIM1 (0.78) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL3139598 0.86 GSK3B (0.78) CCNE2CDK4CCND1CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200206188-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS M (US) 2020-07-02 US claimed
US-20160243077-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS M (US) 2016-08-25 US claimed
US-20150087687-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS (US) 2015-03-26 US claimed
EP-2827869-A2 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO Brown, Dennis (US) 2015-01-28 EP claimed
WO-2013142817-A2 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS (US) 2013-09-26 WO claimed
US-20060217368-A1 Drug for nerve regeneration KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-09-28 US claimed
EP-1645286-A1 DRUG FOR NERVE REGENERATION KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-04-12 EP claimed
EP-1140070-A1 TREATMENT OF CONDITIONS WITH A NEED FOR THE INHIBITION OF GSK-3 SMITHKLINE BEECHAM PLC (GB) 2001-10-10 EP claimed
WO-2000038675-A1 TREATMENT OF CONDITIONS WITH A NEED FOR THE INHIBITION OF GSK-3 SMITHKLINE BEECHAM PLC (GB) 2000-07-06 WO claimed
US-20230100193-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME CYTODIGM, INC. 2023-03-30 US disclosed
US-20200383931-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME CYTODIGM, INC. 2020-12-10 US disclosed
US-20200206188-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS M (US) 2020-07-02 US disclosed
EP-3600259-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME Phosphorex, Inc. (US) 2020-02-05 EP disclosed
CN-110709066-A Novel pharmaceutical formulations containing indirubin and derivatives thereof and methods of making and using the same 法斯瑞斯公司 2020-01-17 CN disclosed
WO-2005028678-A9 METHODS AND MATERIALS FOR IDENTIFYING AGENTS WHICH MODULATE BONE REMODELING AND AGENTS IDENTIFIED THEREBY WYETH CORP (US) 2006-08-31 WO disclosed
EP-1645286-A1 DRUG FOR NERVE REGENERATION KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-04-12 EP disclosed
EP-1636388-A2 METHODS AND MATERIALS FOR IDENTIFYING AGENTS WHICH MODULATE BONE REMODELING AND AGENTS IDENTIFIED THEREBY Wyeth (US) 2006-03-22 EP disclosed
WO-2005028678-A2 METHODS AND MATERIALS FOR IDENTIFYING AGENTS WHICH MODULATE BONE REMODELING AND AGENTS IDENTIFIED THEREBY WYETH (US) 2005-03-31 WO disclosed
EP-1140070-A1 TREATMENT OF CONDITIONS WITH A NEED FOR THE INHIBITION OF GSK-3 SMITHKLINE BEECHAM PLC (GB) 2001-10-10 EP disclosed
WO-2000038675-A1 TREATMENT OF CONDITIONS WITH A NEED FOR THE INHIBITION OF GSK-3 SMITHKLINE BEECHAM PLC (GB) 2000-07-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230100193-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME UGT2B7, UGT1A7, CYP3A7 CCNE2 1433/4885CDK4 1568/4885CCND1 2968/4885
US-20060217368-A1 Drug for nerve regeneration GSK3A, BDNF, GSK3B CCNE2 2297/4885CDK4 85/4885CCND1 1989/4885
US-20200383931-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME UGT2B7, UGT1A7, CYP3A7 CCNE2 1433/4885CDK4 1568/4885CCND1 2968/4885
US-20200206188-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO NEK9, NEK7, NEK3 CCNE2 2620/4885CDK4 689/4885CCND1 2386/4885
US-20150087687-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO CYP7A1, CYP3A7, UGT2B7 CCNE2 2755/4885CDK4 1596/4885CCND1 3364/4885
US-20160243077-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO NEK9, NEK7, NEK3 CCNE2 2620/4885CDK4 689/4885CCND1 2386/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.