Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683505 | 0.91 | LMNA (0.51) | LMNAKMT2ATHRBMAPTMEN1 | |
| SCHEMBL5681631 | 0.81 | KDM4E (0.58) | LMNAKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL10341159 | 0.76 | LMNA (0.55) | LMNAKMT2ATHRBMAPTMEN1 | |
| SCHEMBL7057720 | 0.73 | THRB (0.59) | LMNAKMT2ATHRBMAPTMEN1 | |
| SCHEMBL3296359 | 0.71 | LMNA (0.52) | LMNAKMT2ATHRBMAPTMEN1 | |
| SCHEMBL10086154 | 0.71 | LMNA (0.60) | LMNAKMT2ATHRBMAPTMEN1 | |
| SCHEMBL29766728 | 0.70 | LMNA (0.50) | LMNAKMT2ATHRBMAPTMEN1 | |
| SCHEMBL6050608 | 0.70 | KMT2A (0.49) | LMNAKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL4141591 | 0.69 | LMNA (0.61) | LMNAKMT2ATHRBMAPTMEN1 | |
| SCHEMBL1431209 | 0.69 | LMNA (0.57) | LMNAKMT2ATHRBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831869-B1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-0831869-A4 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0831869-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | Elizanor Biopharmaceuticals, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040190-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |