Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003393 | 0.88 | LMNA (0.54) | THRBLMNAKMT2AMAPTP2RX3 | |
| SCHEMBL7056189 | 0.85 | LMNA (0.56) | THRBLMNAKMT2AMAPTRXFP1 | |
| SCHEMBL2930235 | 0.82 | THRB (0.63) | THRBLMNAKMT2AMAPTRXFP1 | |
| SCHEMBL5962230 | 0.82 | LMNA (0.53) | THRBLMNAKMT2AMAPTP2RX3 | |
| SCHEMBL7123296 | 0.81 | P2RX3 (0.55) | LMNAKMT2AMAPTP2RX3MEN1 | |
| SCHEMBL10341159 | 0.79 | LMNA (0.55) | THRBLMNAKMT2AMAPTMEN1 | |
| SCHEMBL7055648 | 0.78 | PDE4A (0.66) | THRBKMT2AMAPTRXFP1MEN1 | |
| Hydrochloric Acid SCHEMBL7058185 | 0.78 | PDE4A (0.65) | THRBKMT2AMAPTRXFP1MEN1 | |
| SCHEMBL2937117 | 0.78 | THRB (0.62) | THRBKMT2AMAPTRXFP1MEN1 | |
| SCHEMBL17346999 | 0.77 | LMNA (0.76) | THRBLMNAKMT2AMAPTP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841929-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-07 | — | — | EP | disclosed |
| US-5891878-A | Quinolones and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |