Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5683755 | 1.00 | HDAC8 (0.46) | HDAC8POLBSLC29A1RAB9AALDH1A1 | |
| SCHEMBL5679677 | 0.87 | TP53 (0.47) | HDAC8ALDH1A1KDM4EMEN1KMT2A | |
| Fumaric Acid SCHEMBL4772454 | 0.78 | SLC29A1 (0.46) | POLBSLC29A1ALDH1A1MEN1KMT2A | |
| Fumaric Acid SCHEMBL4772459 | 0.78 | SLC29A1 (0.46) | POLBSLC29A1ALDH1A1MEN1KMT2A | |
| Fumaric Acid SCHEMBL6166760 | 0.76 | POLB (0.57) | POLBSLC29A1RAB9AALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL6166765 | 0.76 | POLB (0.57) | POLBSLC29A1RAB9AALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL4774701 | 0.75 | POLB (0.50) | POLBALDH1A1KDM4EMEN1KMT2A | |
| Fumaric Acid SCHEMBL4774692 | 0.75 | POLB (0.50) | POLBALDH1A1KDM4EMEN1KMT2A | |
| Fumaric Acid SCHEMBL4772608 | 0.75 | MCL1 (0.46) | POLBALDH1A1MEN1KMT2ACYP3A4 | |
| Fumaric Acid SCHEMBL4772611 | 0.75 | MCL1 (0.46) | POLBALDH1A1MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403249-B1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | KOWA CO (JP) | 2006-03-15 | — | — | EP | disclosed |
| EP-1403249-A1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | Kowa Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-6509329-B1 | Inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation | KOWA CO., LTD. (JP) | 2003-01-21 | — | — | US | disclosed |