Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6166760 | 1.00 | POLB (0.57) | POLBMEN1KMT2ARAB9AALDH1A1 | |
| Fumaric Acid SCHEMBL4774701 | 0.91 | POLB (0.50) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL4774692 | 0.91 | POLB (0.50) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL7156863 | 0.90 | POLB (0.44) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL4769418 | 0.90 | KDM4E (0.51) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL7156862 | 0.90 | POLB (0.44) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL4769416 | 0.90 | KDM4E (0.51) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL4772459 | 0.90 | SLC29A1 (0.46) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL4772454 | 0.90 | SLC29A1 (0.46) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL6167681 | 0.89 | POLB (0.53) | POLBMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494670-A1 | MEDICINE FOR TREATING CANCER | Kowa Co., Ltd. (JP) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086397-A1 | MEDICINE FOR TREATING CANCER | KOWA CO., LTD. (JP) | 2003-10-23 | — | — | WO | disclosed |