Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5684150 | 1.00 | MAOB (0.51) | MAOBMAOASCN9AHTR2CHTR2B | |
| Ethane SCHEMBL7865865 | 0.98 | MAOB (0.52) | MAOBMAOASCN9AHTR2CHTR2B | |
| Cyclopropane SCHEMBL7860821 | 0.97 | HTR2C (0.50) | MAOBMAOASCN9AHTR2CHTR2B | |
| SCHEMBL5684469 | 0.90 | ULK1 (0.51) | HTR2CHTR2BKMT2A | |
| SCHEMBL5695724 | 0.90 | ULK1 (0.51) | HTR2CHTR2BKMT2A | |
| SCHEMBL5684479 | 0.90 | ULK1 (0.51) | HTR2CHTR2BKMT2A | |
| SCHEMBL5682167 | 0.88 | LTA4H (0.46) | MAOBMAOASCN9AKMT2A | |
| SCHEMBL1070319 | 0.84 | MAOB (0.72) | MAOBMAOASCN9APPARA | |
| SCHEMBL5680157 | 0.84 | MAOB (0.72) | MAOBMAOASCN9APPARA | |
| SCHEMBL5695674 | 0.82 | ACACB (0.46) | MAOBMAOASCN9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044186-B9 | SUBSTITUTED 2-BENZYLAMINO-2-PHENYL-ACETAMIDE COMPOUNDS | NEWRON PHARM SPA (IT) | 2006-06-21 | — | — | EP | disclosed |
| EP-1044186-B1 | SUBSTITUTED 2-BENZYLAMINO-2-PHENYL-ACETAMIDE COMPOUNDS | NEWRON PHARM SPA (IT) | 2006-03-08 | — | — | EP | disclosed |
| US-6303819-B1 | SODIUM CHANNEL-BLOCKING AGENT; CHRONIC OR NEUROPATHIC PAIN. | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2001-10-16 | — | — | US | disclosed |