Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11390274 | 0.74 | ABCG2 (0.50) | CYP1A2CYP1B1ABCG2PTGS2PTGS1 | |
| SCHEMBL12722842 | 0.73 | PTGS2 (0.48) | CYP1A2CYP1B1ABCG2PTGS2PTGS1 | |
| SCHEMBL14302835 | 0.73 | CYP1A2 (0.51) | CYP1A2CYP1B1ABCG2PTGS2PTGS1 | |
| SCHEMBL7314594 | 0.70 | POLB (0.49) | CYP1A2CYP1B1PTGS2PTGS1MEN1 | |
| SCHEMBL4556560 | 0.69 | BACE1 (0.45) | CYP1A2CYP1B1ADORA3ADORA2AADORA1 | |
| SCHEMBL13346867 | 0.69 | ESR2 (0.40) | CYP1A2CYP1B1ABCG2PTGS2PTGS1 | |
| SCHEMBL1664233 | 0.69 | TP53 (0.48) | CYP1A2PTGS2PTGS1PKMMEN1 | |
| SCHEMBL29693292 | 0.69 | PTGS2 (0.48) | CYP1A2CYP1B1PTGS2PTGS1PKM | |
| SCHEMBL915780 | 0.69 | PTGS2 (0.48) | CYP1A2CYP1B1PTGS2PTGS1PKM | |
| SCHEMBL17876319 | 0.68 | PTPRC (0.53) | ABCG2PTGS2PKMTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353358-B1 | BIS(METHYLENEDIOXY)BIPHENYL COMPOUNDS | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1993-08-18 | — | — | EP | claimed |
| EP-0353358-A1 | Bis(methylenedioxy)biphenyl compounds | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1990-02-07 | — | — | EP | claimed |
| US-4868207-A | Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1989-09-19 | — | — | US | claimed |
| CN-104402856-B | Preparation method of bis(methylenedioxy) biphenyl derivative compound | 浙江东亚药业有限公司 | 2017-05-03 | — | — | CN | disclosed |
| CN-104402856-B | Preparation method of bis(methylenedioxy) biphenyl derivative compound | 浙江东亚药业有限公司 | 2017-05-03 | — | — | CN | disclosed |
| CN-104402856-A | Preparation method of bis(methylenedioxy) biphenyl derivative compound | ZHEJIANG EAST ASIA PHARMACEUTICAL CO LTD | 2015-03-11 | — | — | CN | disclosed |
| CN-104402856-A | Preparation method of bis(methylenedioxy) biphenyl derivative compound | ZHEJIANG EAST ASIA PHARMACEUTICAL CO LTD | 2015-03-11 | — | — | CN | disclosed |
| EP-0837677-B1 | BROMINATED HEXAHYDROXYBIPHENYL DERIVATIVES | UNIV NORTH CAROLINA (US) | 2006-03-29 | — | — | EP | disclosed |
| EP-0837677-A4 | BROMINATED HEXAHYDROXYBIPHENYL DERIVATIVES | UNIV NORTH CAROLINA (US) | 1999-12-15 | — | — | EP | disclosed |
| EP-0837677-A1 | BROMINATED HEXAHYDROXYBIPHENYL DERIVATIVES | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5612341-A | BIS-BENZODIOXOLE COMPOUNDS, TREATMENT OF HIV, VIRICIDES | BIOTECH RESEARCH LABORATORIES (US) | 1997-03-18 | — | — | US | disclosed |
| WO-1996040111-A1 | BROMINATED HEXAHYDROXYBIPHENYL DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0353358-B1 | BIS(METHYLENEDIOXY)BIPHENYL COMPOUNDS | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1993-08-18 | — | — | EP | disclosed |
| EP-0353358-A1 | Bis(methylenedioxy)biphenyl compounds | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1990-02-07 | — | — | EP | disclosed |
| EP-0353358-A1 | Bis(methylenedioxy)biphenyl compounds | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1990-02-07 | — | — | EP | disclosed |
| EP-0353358-A1 | Bis(methylenedioxy)biphenyl compounds | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1990-02-07 | — | — | EP | disclosed |
| US-4868207-A | Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1989-09-19 | — | — | US | disclosed |
| US-4868207-A | Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1989-09-19 | — | — | US | disclosed |
| US-4868207-A | Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1989-09-19 | — | — | US | disclosed |