SCHEMBL1664233

SCHEMBL1664233

O=C(O)c1cc2c(cc1-c1ccccc1)OCO2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.48
DHODH Q02127 1/20 0.48
ALDH1A1 P00352 2/20 0.47
MAPK1 P28482 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
CYP1A2 P05177 2/20 0.46
HIF1A Q16665 1/20 0.46
PTGS2 P35354 4/20 0.45
PTGS1 P23219 3/20 0.45
FOLH1 Q04609 1/20 0.45
PTPN1 P18031 1/20 0.45
NPC1 O15118 2/20 0.44
PKM P14618 2/20 0.44
RAB9A P51151 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
HNF4A P41235 1/20 0.43
FABP3 P05413 1/20 0.43
FABP4 P15090 1/20 0.43
FABP5 Q01469 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9616253 0.85 NR1H4 (0.52) TP53DHODHALDH1A1MAPK1SMN1; SMN2
SCHEMBL667582 0.79 PTPN1 (0.59) ALDH1A1FOLH1PTPN1HNF4AFABP3
SCHEMBL29921207 0.79 ALDH1A1 (0.57) TP53DHODHALDH1A1MAPK1SMN1; SMN2
SCHEMBL7370339 0.79 ALDH1A1 (0.57) TP53DHODHALDH1A1MAPK1SMN1; SMN2
SCHEMBL4684053 0.78 FABP4 (0.48) FOLH1PTPN1NPC1RAB9AFABP3
SCHEMBL26599226 0.77 NPC1 (0.50) TP53ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL31207954 0.77 NPC1 (0.50) TP53ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL9171492 0.77 PTPN1 (0.57) ALDH1A1FOLH1PTPN1HNF4AFABP3
SCHEMBL20241896 0.77 BCAT2 (0.51) ALDH1A1SMN1; SMN2NPC1RAB9ACTNNB1
SCHEMBL22256426 0.76 KMT2A (0.50) TP53ALDH1A1MAPK1SMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885192-B8 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) 2012-05-16 EP disclosed
EP-2311806-A2 Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists The United States of America, Represented by the Secretary, Department of Health and Human Services (US) 2011-04-20 EP disclosed
US-6066642-A FOR SELECTIVELY BLOCKING THE A3 ADENOSINE RECEPTOR OF A MAMMAL THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-05-23 US disclosed
EP-0885192-A1 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1998-12-23 EP disclosed
WO-1997027177-A2 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN-4-ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-07-31 WO disclosed