Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 15/20 | 0.63 |
| ▸ | CTSK | P43235 | 12/20 | 0.63 |
| ▸ | CTSL | P07711 | 4/20 | 0.63 |
| ▸ | CTSB | P07858 | 4/20 | 0.63 |
| ▸ | REN | P00797 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418512 | 0.85 | REN (0.65) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL14485901 | 0.85 | CTSS (0.74) | CTSSCTSKCTSLCTSB | |
| SCHEMBL5557532 | 0.83 | REN (0.49) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL8107172 | 0.82 | CTSS (0.64) | CTSSCTSKCTSLCTSB | |
| SCHEMBL7980282 | 0.82 | CTSS (0.64) | CTSSCTSKCTSLCTSB | |
| SCHEMBL15308916 | 0.82 | CTSS (0.60) | CTSSCTSKCTSLCTSB | |
| SCHEMBL15702860 | 0.81 | CTSS (0.58) | CTSSCTSKCTSLCTSB | |
| SCHEMBL8771983 | 0.81 | CTSL (0.55) | CTSSCTSKCTSLCTSBREN | |
| SCHEMBL3274015 | 0.80 | EPHX2 (0.58) | CTSSCTSKCTSLCTSB | |
| SCHEMBL22522212 | 0.80 | CTSL (0.54) | CTSSCTSKCTSLCTSBREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294395-B1 | A COMBINATION PRODUCT COMPRISING MELAGATRAN AND A FACTOR VIIa INHIBITOR | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-20030153506-A1 | Combination product comprising melagatran and factor VIIa inhibitor | ASTRAZENECA AB (SE) | 2003-08-14 | — | — | US | disclosed |