Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5689006 | 0.87 | PTPN11 (0.47) | SGMS2GAAMEN1KMT2A | |
| SCHEMBL5686120 | 0.87 | RAB9A (0.53) | SGMS2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4559143 | 0.81 | KMT2A (0.51) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5686380 | 0.80 | ATR (0.48) | SGMS2 | |
| SCHEMBL4559637 | 0.77 | PTPN11 (0.45) | GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL4559175 | 0.76 | MEN1 (0.55) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL875474 | 0.76 | SGMS2 (1.00) | SGMS2GAAMEN1KMT2ANPC1 | |
| SCHEMBL3979493 | 0.75 | EGFR (0.67) | SGMS2GAALRRK2 | |
| SCHEMBL11298985 | 0.74 | PTPN11 (0.63) | MEN1KMT2AALDH1A1 | |
| SCHEMBL16465324 | 0.71 | PRKCI (0.52) | MEN1KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |