Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686325 | 0.85 | RAB9A (0.56) | SMN1; SMN2RAB9AJAK2 | |
| SCHEMBL357927 | 0.83 | ALDH1A1 (0.71) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 | |
| Hydrochloric Acid SCHEMBL5013604 | 0.82 | ALDH1A1 (0.69) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 | |
| SCHEMBL4504400 | 0.80 | RAB9A (0.52) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 | |
| SCHEMBL12392903 | 0.79 | MAPT (0.65) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 | |
| SCHEMBL28694330 | 0.78 | ALDH1A1 (0.64) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 | |
| SCHEMBL2267512 | 0.76 | MAPT (0.64) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 | |
| SCHEMBL15273383 | 0.75 | RAB9A (0.48) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 | |
| SCHEMBL15273051 | 0.75 | BTK (0.52) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 | |
| SCHEMBL21379546 | 0.75 | MAPT (0.70) | MAPTSMN1; SMN2CYP1A2LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |