Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 4/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686243 | 0.85 | MAPT (0.55) | RAB9ASMN1; SMN2JAK2 | |
| SCHEMBL4492001 | 0.85 | SYK (0.62) | SYKCDK4CCND1CDK6LCK | |
| SCHEMBL4460927 | 0.83 | RAB9A (0.56) | RAB9AL3MBTL1SMN1; SMN2KMT2AHRH3 | |
| Hydrochloric Acid SCHEMBL5009801 | 0.82 | RAB9A (0.55) | RAB9AL3MBTL1SMN1; SMN2KMT2AHRH3 | |
| SCHEMBL29883723 | 0.80 | L3MBTL1 (0.52) | RAB9AL3MBTL1SMN1; SMN2SYKCCNT1 | |
| SCHEMBL1431034 | 0.79 | RAB9A (0.67) | RAB9AL3MBTL1SMN1; SMN2CCNT1CDK4 | |
| SCHEMBL5686213 | 0.79 | FLT3 (0.58) | SYKJAK3LCKJAK2JAK1 | |
| SCHEMBL4506714 | 0.78 | PKMYT1 (0.60) | EGFR | |
| SCHEMBL4494959 | 0.76 | STAT6 (0.59) | SYKJAK3 | |
| SCHEMBL4489867 | 0.75 | BRD4 (0.61) | SYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |