Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683363 | 0.94 | LMNA (0.50) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL6414232 | 0.90 | GPR119 (0.56) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL7078017 | 0.90 | MAPT (0.60) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL2724586 | 0.81 | MAPT (0.53) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL31342653 | 0.81 | ALK (0.51) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL19459053 | 0.81 | ALK (0.51) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL24847981 | 0.80 | MAPT (0.49) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL5573222 | 0.80 | MAPT (0.76) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL8257643 | 0.80 | MAPT (0.64) | MAPTLMNAALDH1A1PDK2GPR119 | |
| SCHEMBL25307735 | 0.80 | GPR119 (0.62) | MAPTGPR119RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1645556-A1 | Arylpiperazine-benzoylamide derivatives useful as pharmaceutical agents | Boehringer Ingelheim International GmbH (DE) | 2006-04-12 | — | — | EP | disclosed |