Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686248 | 0.90 | MAPT (0.53) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL15703241 | 0.88 | MAPT (0.61) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL6414232 | 0.87 | GPR119 (0.56) | MAPTLMNAALDH1A1GPR119NAMPT | |
| SCHEMBL5683363 | 0.86 | LMNA (0.50) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL5573222 | 0.86 | MAPT (0.76) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL8257643 | 0.85 | MAPT (0.64) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL3938884 | 0.85 | MAPT (0.57) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL5235779 | 0.84 | MAPT (0.56) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL1458624 | 0.83 | L3MBTL1 (0.73) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL2097736 | 0.83 | MAPT (0.65) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |