Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557970 | 0.82 | TSHR (0.46) | RORCTSHRPTPN1 | |
| SCHEMBL4559145 | 0.80 | ADORA2A (0.56) | BTKADORA2AADORA1MEN1GAA | |
| SCHEMBL5686147 | 0.78 | MGMT (0.45) | KDM4EALDH1A1ADORA2AADORA1 | |
| SCHEMBL5689008 | 0.78 | LMNA (0.43) | KDM4EALDH1A1HPGDADORA2AADORA1 | |
| SCHEMBL4559639 | 0.78 | ADORA2A (0.39) | KDM4EALDH1A1ADORA2AADORA1MEN1 | |
| SCHEMBL4559176 | 0.75 | SIRT2 (0.45) | BTKKDM4EALDH1A1ADORA2AADORA1 | |
| SCHEMBL5686125 | 0.71 | PARP10 (0.50) | BTKADORA2AGAA | |
| SCHEMBL16465331 | 0.71 | GAA (0.45) | KDM4EALDH1A1ADORA2AADORA1MEN1 | |
| SCHEMBL12495739 | 0.69 | RORC (0.47) | RORCKDM4EALDH1A1MEN1GAA | |
| SCHEMBL4559387 | 0.68 | LMNA (0.45) | BTKALDH1A1ADORA2ALMNASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |