Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 11/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686503 | 0.91 | SYK (0.51) | SYKCASP1ITGB3ITGA2BCTSL | |
| SCHEMBL25256638 | 0.89 | SYK (0.62) | SYKCASP1ITGB3ITGA2BCTSL | |
| SCHEMBL25301720 | 0.89 | SYK (0.62) | SYKCASP1ITGB3ITGA2BCTSL | |
| SCHEMBL6685926 | 0.81 | SYK (0.59) | SYKCASP1CTSLCTRB1 | |
| SCHEMBL6685929 | 0.81 | SYK (0.59) | SYKCASP1CTSLCTRB1 | |
| SCHEMBL12849405 | 0.81 | SYK (0.72) | SYKCASP1CTSLCTRB1 | |
| SCHEMBL5197783 | 0.81 | SYK (0.62) | SYKCASP1CTSLCTRB1 | |
| SCHEMBL7360200 | 0.81 | CTRB1 (0.62) | SYKITGB3ITGA2BCTSLCTRB1 | |
| SCHEMBL7360205 | 0.81 | CTRB1 (0.62) | SYKITGB3ITGA2BCTSLCTRB1 | |
| SCHEMBL7496788 | 0.81 | SYK (0.62) | SYKCASP1CTSLCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979241-B1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | IVAX DRUG RES INST LTD (HU) | 2006-03-01 | — | — | EP | disclosed |
| US-6593300-B1 | Inhibitors of the interleukin-1 beta converting enzyme | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2003-07-15 | — | — | US | disclosed |
| EP-0979241-A1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998049189-A1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | Gyógyszerkutató Intézet Kft. (HU) | 1998-11-05 | — | — | WO | disclosed |