Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 8/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL5686500 | 0.91 | SYK (0.52) | SYKITGB3ITGA2BCASP1CTSL | |
| SCHEMBL25256638 | 0.89 | SYK (0.62) | SYKITGB3ITGA2BCASP1CTSL | |
| SCHEMBL25301720 | 0.89 | SYK (0.62) | SYKITGB3ITGA2BCASP1CTSL | |
| SCHEMBL29398786 | 0.87 | CACNA1B (0.50) | SYKALDH1A1ITGB3ITGA2BCASP1 | |
| SCHEMBL11027577 | 0.82 | ALDH1A1 (0.47) | SYKALDH1A1ITGB3ITGA2BEPHX1 | |
| SCHEMBL11169588 | 0.82 | ALDH1A1 (0.47) | SYKALDH1A1ITGB3ITGA2BEPHX1 | |
| SCHEMBL29787920 | 0.82 | ALDH1A1 (0.47) | SYKALDH1A1ITGB3ITGA2BEPHX1 | |
| SCHEMBL10681835 | 0.81 | REN (0.47) | SYKALDH1A1CASP1CTSL | |
| SCHEMBL9574079 | 0.81 | CASP1 (0.54) | ALDH1A1ITGB3ITGA2BCASP1EPHX1 | |
| SCHEMBL29402502 | 0.80 | ITGB3 (0.49) | SYKALDH1A1ITGB3ITGA2BCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979241-B1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | IVAX DRUG RES INST LTD (HU) | 2006-03-01 | — | — | EP | disclosed |
| US-6593300-B1 | Inhibitors of the interleukin-1 beta converting enzyme | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2003-07-15 | — | — | US | disclosed |
| EP-0979241-A1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998049189-A1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | Gyógyszerkutató Intézet Kft. (HU) | 1998-11-05 | — | — | WO | disclosed |