Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6685929 | 1.00 | SYK (0.59) | SYKKLK5KLK7ATMPPARA | |
| SCHEMBL17207697 | 0.93 | SYK (0.59) | SYKKLK5KLK7ATMPPARA | |
| SCHEMBL3108565 | 0.90 | SYK (0.59) | SYKKLK5KLK7ATMPPARA | |
| SCHEMBL3276799 | 0.90 | SYK (0.59) | SYKKLK5KLK7ATMPPARA | |
| SCHEMBL1262680 | 0.90 | SYK (0.59) | SYKKLK5KLK7ATMPPARA | |
| SCHEMBL25301720 | 0.90 | SYK (0.62) | SYKATMCTSSCTSLCASP1 | |
| SCHEMBL15928906 | 0.90 | ATM (0.62) | SYKKLK5KLK7ATMPPARA | |
| SCHEMBL25256638 | 0.90 | SYK (0.62) | SYKATMCTSSCTSLCASP1 | |
| SCHEMBL14119009 | 0.90 | ATM (0.62) | SYKKLK5KLK7ATMPPARA | |
| SCHEMBL25318929 | 0.89 | SYK (0.56) | SYKKLK5KLK7ATMPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114796207-A | Dipeptide mimetics as inhibitors of human immunoproteasome | 康奈尔大学 | 2022-07-29 | — | — | CN | disclosed |
| CN-107073069-B | Dipeptide mimetics as inhibitors of human immunoproteasome | 康奈尔大学 | 2022-03-08 | — | — | CN | disclosed |
| CN-107207465-B | Heterocyclic compounds and their use | 财团法人卫生研究院 | 2021-09-10 | — | — | CN | disclosed |
| EP-3197885-B1 | HETEROCYCLIC COMPOUNDS AND USE THEREOF | NATIONAL HEALTH RES INST (TW) | 2020-11-18 | — | — | EP | disclosed |
| US-9926298-B2 | Heterocyclic compounds and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2018-03-27 | — | — | US | disclosed |
| US-20180009786-A1 | HETEROCYCLIC COMPOUNDS AND USE THEREOF | NATIONAL HEALTH RES INST (TW) | 2018-01-11 | — | — | US | disclosed |
| US-9862703-B2 | Heterocyclic compounds and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2018-01-09 | — | — | US | disclosed |
| EP-3197885-A2 | HETEROCYCLIC COMPOUNDS AND USE THEREOF | Chao, Yu-Sheng (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016048861-A2 | HETEROCYCLIC COMPOUNDS AND USE THEREOF | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2016-03-31 | — | — | WO | disclosed |
| US-20160083369-A1 | HETEROCYCLIC COMPOUNDS AND USE THEREOF | NAT HEALTH RESEARCH INSTITUTES (TW) | 2016-03-24 | — | — | US | disclosed |
| WO-2004089362-A1 | 2-CYANOPYRROLES AND THEIR ANALOGUES AS DDP-IV INHIBITORS | NOVO NORDISK A/S (DK) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009786-A1 | HETEROCYCLIC COMPOUNDS AND USE THEREOF | CXCL12, HPGDS, MCL1 | SYK 790/4885KLK5 3861/4885KLK7 3726/4885 |
| US-20160083369-A1 | HETEROCYCLIC COMPOUNDS AND USE THEREOF | CXCL12, HPGDS, MCL1 | SYK 790/4885KLK5 3861/4885KLK7 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.