SCHEMBL5688672

SCHEMBL5688672

Cc1ccc(Cc2ccc(OC(=O)N3CCC(COc4ccc(Oc5ccc(C)cn5)cc4)CC3)cc2)nc1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LIPE Q05469 10/20 0.52
ACACB O00763 2/20 0.45
GRIN2B Q13224 1/20 0.43
BCHE P06276 1/20 0.43
RXRB P28702 1/20 0.40
ACACA Q13085 1/20 0.40
P2RX3 P56373 1/20 0.39
GPR119 Q8TDV5 1/20 0.39
CHRNA7 P36544 1/20 0.39
CYP4F2 P78329 1/20 0.39
CYP4A11 Q02928 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5688556 0.93 LIPE (0.65) LIPEBCHE
SCHEMBL5688501 0.92 LIPE (0.51) LIPEACACBGRIN2BBCHEACACA
SCHEMBL5688710 0.92 LIPE (0.47) LIPEACACBGRIN2BP2RX3CYP4F2
SCHEMBL5931494 0.92 LIPE (0.51) LIPEACACBGRIN2BBCHERXRB
SCHEMBL5688364 0.91 LIPE (0.48) LIPEACACBGRIN2BBCHEACACA
SCHEMBL5687622 0.90 LIPE (0.48) LIPEACACBGRIN2BBCHEACACA
SCHEMBL5687705 0.88 LIPE (0.49) LIPEACACBBCHERXRBACACA
SCHEMBL5687917 0.88 GRIN2B (0.44) LIPEGRIN2BP2RX3GPR119CYP4F2
SCHEMBL5690554 0.88 GRIN2B (0.44) LIPEGRIN2BP2RX3GPR119CYP4F2
SCHEMBL5689859 0.88 LIPE (0.65) LIPEBCHEP2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US claimed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP claimed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO claimed
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US disclosed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP disclosed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160851-A1 Substituted piperidine carbamates LIPE, PNLIP, LIPC LIPE 1/4885ACACB 180/4885GRIN2B 2588/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.