SCHEMBL5688786

SCHEMBL5688786

CNC(=O)c1cccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)n1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 8/20 0.44
CNR1 P21554 5/20 0.44
CTSA P10619 2/20 0.38
CYP17A1 P05093 4/20 0.37
BRD4 O60885 1/20 0.36
CYP3A4 P08684 1/20 0.36
SIRT2 Q8IXJ6 2/20 0.36
KAT6A Q92794 1/20 0.36
SCN9A Q15858 1/20 0.36
IRAK4 Q9NWZ3 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5688891 0.92 CNR2 (0.43) CNR2CNR1CTSASIRT2SCN9A
SCHEMBL5690711 0.90 P2RY12 (0.41) CNR2CNR1CTSACYP17A1SIRT2
SCHEMBL5689078 0.84 CYP17A1 (0.56) CNR2CNR1CYP17A1CYP3A4SIRT2
SCHEMBL5688704 0.83 CYP17A1 (0.44) CYP17A1CYP3A4SIRT2KAT6A
SCHEMBL5688583 0.83 CYP17A1 (0.56) CYP17A1CYP3A4SIRT2
SCHEMBL5688595 0.82 KDM4E (0.48) CYP17A1CYP3A4SIRT2
SCHEMBL5688555 0.79 CYP17A1 (0.48) CYP17A1CYP3A4KAT6A
SCHEMBL4031099 0.79 CYP17A1 (0.52) CYP17A1CYP3A4SIRT2
SCHEMBL5688570 0.79 CYP17A1 (0.48) CYP17A1CYP3A4SIRT2
SCHEMBL4023981 0.78 CYP17A1 (0.42) CYP17A1CYP3A4SIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1227086-B1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-03-29 EP disclosed
US-6518257-B1 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-02-11 US disclosed
EP-1227086-A1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-07-31 EP disclosed