Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 5/20 | 0.44 |
| ▸ | NPY1R | P25929 | 3/20 | 0.44 |
| ▸ | NPY2R | P49146 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.43 |
| ▸ | IL1RN | P18510 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686933 | 0.88 | OPRD1 (0.41) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5686700 | 0.88 | OPRD1 (0.50) | OPRD1OPRM1OPRK1BACE1BACE2 | |
| SCHEMBL5686852 | 0.85 | OPRD1 (0.43) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5688620 | 0.85 | OPRD1 (0.43) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5687724 | 0.82 | OPRD1 (0.48) | OPRD1OPRM1OPRK1BACE1BACE2 | |
| SCHEMBL5686954 | 0.80 | CTSD (0.44) | OPRD1OPRM1OPRK1BACE1BACE2 | |
| SCHEMBL5689507 | 0.79 | OPRD1 (0.49) | OPRD1BACE1BACE2 | |
| SCHEMBL29436297 | 0.79 | NPY4R (0.58) | NPY4RNPY1RNPY2ROPRD1IL1RN | |
| SCHEMBL30538859 | 0.79 | NPY4R (0.57) | NPY4RNPY1RNPY2ROPRD1IL1RN | |
| SCHEMBL30656945 | 0.78 | NPY4R (0.57) | NPY4RNPY1RNPY2ROPRD1IL1RN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979241-B1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | IVAX DRUG RES INST LTD (HU) | 2006-03-01 | — | — | EP | disclosed |
| US-6593300-B1 | Inhibitors of the interleukin-1 beta converting enzyme | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2003-07-15 | — | — | US | disclosed |
| EP-0979241-A1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998049189-A1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | Gyógyszerkutató Intézet Kft. (HU) | 1998-11-05 | — | — | WO | disclosed |