Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL468813 | 1.00 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL15463836 | 1.00 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL5903143 | 0.94 | LMNA (0.50) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL1792710 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL6662558 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL28918498 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL1134753 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL2487171 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL5161896 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 | |
| Glycerin SCHEMBL468638 | 0.94 | LMNA (0.56) | LMNAALDH1A1SMN1; SMN2THRBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110494098-A | Electrolyte composition containing metal and silicon in plasma electrolysis oxidation process and the dental that the hydroxyapatite containing metal ion and silicon ion is coated with using its composition plant the manufacturing method of tooth | UNIV CHOSUN IACF | 2019-11-22 | — | — | CN | disclosed |
| EP-0832254-B1 | AN AUTOREGULATORY TETRACYCLINE-REGULATED SYSTEM FOR INDUCIBLE GENE EXPRESSION IN EUCARYOTES | UNIV YALE (US) | 2006-03-29 | — | — | EP | disclosed |
| US-5932417-A | EXPOSING CULTURE OF CELLS WHICH TRANSIENTLY EXPRESSES RECEPTOR POTENTIAL PROTEIN TO COMPOUNDS, DETERMINING IF EXPOSURE AFFECTS GENE EXPRESSION OF THAT PROTEIN | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-08-03 | — | — | US | disclosed |
| US-5851796-A | Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes | YALE UNIVERSITY (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0832254-A1 | AN AUTOREGULATORY TETRACYCLINE-REGULATED SYSTEM FOR INDUCIBLE GENE EXPRESSION IN EUCARYOTES | YALE UNIVERSITY (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1998008979-A1 | METHOD AND COMPOUNDS FOR CONTROLLING CAPACITATIVE CALCIUM ION ENTRY INTO MAMMALIAN CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-03-05 | — | — | WO | disclosed |
| WO-1996040946-A1 | AN AUTOREGULATORY TETRACYCLINE-REGULATED SYSTEM FOR INDUCIBLE GENE EXPRESSION IN EUCARYOTES | YALE UNIVERSITY (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1994026890-A1 | HIV-1 TAR RNA BINDING PROTEIN | ISIS INNOVATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |