Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NCF1 | P14598 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31498821 | 0.79 | NCF1 (0.50) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| SCHEMBL1131286 | 0.79 | NCF1 (0.50) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| Phosphine SCHEMBL23753735 | 0.77 | MAPT (0.49) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| SCHEMBL5593982 | 0.76 | MAPT (0.47) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| SCHEMBL6750168 | 0.76 | MAPT (0.47) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| SCHEMBL6026855 | 0.76 | MAPT (0.47) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| SCHEMBL17440166 | 0.76 | MAPT (0.47) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| SCHEMBL7942319 | 0.76 | MAPT (0.47) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| SCHEMBL4458474 | 0.76 | MAPT (0.47) | MAPTMEN1KMT2ANCF1CYP1A2 | |
| SCHEMBL9826905 | 0.76 | NCF1 (0.52) | MAPTMEN1KMT2ANCF1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091272-B2 | Olefin polymerization with pyridine moiety-containing single-site catalysts | EQUISTAR CHEMICALS, LP (US) | 2006-08-15 | — | — | US | claimed |
| EP-1644419-A1 | OLEFIN POLYMERIZATION WITH PYRIDINE MOIETY-CONTAINING SINGLE-SITE CATALYSTS | Equistar Chemicals, LP (US) | 2006-04-12 | — | — | EP | claimed |
| WO-2005007708-A1 | OLEFIN POLYMERIZATION WITH PYRIDINE MOIETY-CONTAINING SINGLE-SITE CATALYSTS | EQUISTAR CHEMICALS, LP (US) | 2005-01-27 | — | — | WO | claimed |
| US-20050014915-A1 | Olefin polymerization with pyridine moiety-containing single-site catalysts | EQUISTAR CHEMICALS, LP | 2005-01-20 | — | — | US | claimed |
| US-6767975-B1 | IN PRESENCE OF CLAY, ACTIVATOR, AND TRANSITION METAL COMPLEX; ADDITION POLYMERIZATION OF ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE; BULK DENSITY | EQUISTAR CHEMICALS, LP | 2004-07-27 | — | — | US | claimed |
| US-9120089-B2 | Catalyst support used for olefin polymerization and preparing method and application thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2015-09-01 | — | — | US | disclosed |
| US-20120130034-A1 | CATALYST SUPPORT USED FOR OLEFIN POLYMERIZATION AND PREPARING METHOD AND APPLICATION THEREOF | ZHEJIANG UNIVERSITY (CN) | 2012-05-24 | — | — | US | disclosed |
| US-6635728-B2 | Preparation of ultra-high-molecular-weight polyethylene | EQUISTAR CHEMICALS, LP | 2003-10-21 | — | — | US | disclosed |
| WO-2003059968-A1 | PREPARATION OF ULTRA-HIGH-MOLECULAR-WEIGHT POLYETHYLENE | EQUISTAR CHEMICALS, LP (US) | 2003-07-24 | — | — | WO | disclosed |
| US-20030130448-A1 | PREPARATION OF ULTRA-HIGH-MOLECULAR-WEIGHT POLYETHYLENE | EQUISTAR CHEMICALS, LP | 2003-07-10 | — | — | US | disclosed |