Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058325 | 0.85 | SIRT6 (0.42) | MAPTTDP1POLBALDH1A1LMNA | |
| SCHEMBL3050943 | 0.83 | ALDH1A1 (0.50) | MAPTTDP1POLBALDH1A1LMNA | |
| SCHEMBL5692143 | 0.76 | ALDH1A1 (0.34) | MAPTTDP1POLBALDH1A1LMNA | |
| SCHEMBL3049898 | 0.75 | MAPT (0.64) | MAPTALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL5164284 | 0.74 | ALDH1A1 (0.54) | MAPTTDP1POLBALDH1A1LMNA | |
| SCHEMBL5692137 | 0.74 | MAPT (0.40) | MAPTTDP1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9655029 | 0.72 | ALDH1A1 (0.49) | MAPTTDP1POLBALDH1A1LMNA | |
| SCHEMBL5691992 | 0.72 | CRHR1 (0.41) | MAPTTDP1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5452124 | 0.71 | MAPT (0.60) | MAPTALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL31138869 | 0.71 | ALDH1A1 (0.53) | TDP1POLBALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654221-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005000795-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | claimed |