Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 3/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.33 |
| ▸ | GLI1 | P08151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL29222914 | 1.00 | GRIK1 (0.37) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Aspartic Acid SCHEMBL1680031 | 0.95 | GRIK1 (0.40) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Aspartic Acid SCHEMBL22436907 | 0.95 | GRIK1 (0.40) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Aspartic Acid SCHEMBL537633 | 0.95 | GRIK1 (0.40) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Asparagine SCHEMBL4607285 | 0.92 | NOS2 (0.37) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Asparagine SCHEMBL4404357 | 0.92 | NOS2 (0.37) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Glutamine SCHEMBL3442669 | 0.90 | ALOX15 (0.45) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Aspartic Acid SCHEMBL27659271 | 0.90 | GRIK1 (0.36) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Aspartic Acid SCHEMBL3432993 | 0.90 | GRIK1 (0.36) | GRIK1GRIK2NOS2NOS3NOS1 | |
| Proline SCHEMBL181143 | 0.88 | NOS2 (0.35) | GRIK1GRIK2NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115466305-A | Almond small molecule peptide for inhibiting activity of alpha-glucosidase and application thereof | 重庆三峡学院 | 2022-12-13 | — | — | CN | disclosed |
| EP-0904410-B1 | IDENTIFICATION OF PYRAZINAMIDE-RESISTANT MYCOBACTERIA AND METHODS FOR TREATING MYCOBACTERIAL INFECTIONS | UNIV JOHNS HOPKINS (US) | 2006-05-17 | — | — | EP | disclosed |
| EP-0904410-A4 | IDENTIFICATION OF PYRAZINAMIDE-RESISTANT MYCOBACTERIA AND METHODS FOR TREATING MYCOBACTERIAL INFECTIONS | UNIV JOHNS HOPKINS (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0904410-A1 | IDENTIFICATION OF PYRAZINAMIDE-RESISTANT MYCOBACTERIA AND METHODS FOR TREATING MYCOBACTERIAL INFECTIONS | THE JOHNS HOPKINS UNIVERSITY (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5846718-A | Identification of pyrazinamide-resistant mycobacteria and methods for treating mycobacterial infections | THE JOHNS HOPKINS UNIVERSITY (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997045558-A1 | IDENTIFICATION OF PYRAZINAMIDE-RESISTANT MYCOBACTERIA AND METHODS FOR TREATING MYCOBACTERIAL INFECTIONS | THE JOHNS HOPKINS UNIVERSITY (US) | 1997-12-04 | — | — | WO | disclosed |