Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9187478 | 0.88 | DHFR (0.41) | DHFRGABRA1GABRB2BACE1CYP3A4 | |
| SCHEMBL5692145 | 0.86 | DHFR (0.42) | DHFRGABRA1GABRB2CYP3A4PTGS2 | |
| SCHEMBL14370359 | 0.85 | DHFR (0.40) | DHFRGABRA1GABRB2BACE1CYP3A4 | |
| SCHEMBL5692024 | 0.83 | HTT (0.43) | CYP3A4PTGS2KMT2AHPGDMAPK1 | |
| SCHEMBL5692470 | 0.79 | GABRA1 (0.46) | GABRA1GABRB2MAPK1ALDH1A1NPC1 | |
| SCHEMBL1023550 | 0.79 | DHFR (0.47) | DHFRGABRA1GABRB2BACE1CYP3A4 | |
| SCHEMBL28293473 | 0.76 | PTGS2 (0.33) | PTGS2 | |
| SCHEMBL581480 | 0.75 | GABRA1 (0.52) | DHFRGABRA1GABRB2BACE1CYP3A4 | |
| SCHEMBL1023576 | 0.75 | DHFR (0.53) | DHFRGABRA1GABRB2BACE1CYP3A4 | |
| SCHEMBL5692263 | 0.75 | PTGS1 (0.50) | PTGS2GAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532400-A | 2,6-di-alkyl-4-silyl-phenols as antiatheroscelerotic agents | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-02 | — | — | US | claimed |
| EP-0464852-B1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1996-03-20 | — | — | EP | claimed |
| EP-0464852-A1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | claimed |
| EP-1468692-B1 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMA INC (US) | 2006-04-26 | — | — | EP | disclosed |
| EP-0732928-B1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMA INC (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-1468693-A2 | Use of 2,6-di -alkyl-4-silyl-phenols for treating diabetes mellitus | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1468692-A2 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| CN-1092517-C | Method for lowering serum cholesterol levels using 2, 6-dialkyl-4-silyl-phenols | MERRELL DOW PHARMA (US) | 2002-10-16 | — | — | CN | disclosed |
| CN-1216921-A | Method for inducing vascular cell adhesion molecule-1 and treating chronic inflammatory diseases using 2, 6-dialkyl-4-silyl-phenols | HOECHST MARION ROUSSEL INC (US) | 1999-05-19 | — | — | CN | disclosed |
| EP-0910384-A1 | METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-28 | — | — | EP | disclosed |
| US-5795876-A | ANTIINFLAMMATORY AGENTS | HOECHST MARION ROUSSSEL, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| WO-1997040837-A1 | METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-06 | — | — | WO | disclosed |
| CN-1140995-A | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols | MERRELL DOW PHARMA (US) | 1997-01-22 | — | — | CN | disclosed |
| US-5532400-A | 2,6-di-alkyl-4-silyl-phenols as antiatheroscelerotic agents | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0464852-B1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| CN-1029615-C | Novel 2,6-Di-alkyl-4-silyl-phenols as antiatherosclerotic agents | MERRELL DOW PHARMA (US) | 1995-08-30 | — | — | CN | disclosed |
| US-5155250-A | 2,6-DI-ALKYL-4-SILYL-PHENOLS AS ANTIATHEROSCEROTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-13 | — | — | US | disclosed |
| CN-1057843-A | New 2 as antiatherosclerotic, 6-two-alkyl-4-silyl-phenols | MERRELL DOW PHARMA (US) | 1992-01-15 | — | — | CN | disclosed |
| EP-0464852-A1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |