Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570105 | 0.81 | NPC1 (0.43) | HDAC3HDAC1NPC1RAB9AGAA | |
| SCHEMBL569981 | 0.80 | L3MBTL1 (0.43) | HDAC3NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL569267 | 0.77 | MAPT (0.42) | NPC1RAB9ASMN1; SMN2HPGDGAA | |
| SCHEMBL14955270 | 0.76 | HDAC6 (0.46) | HDAC3HDAC1HDAC6NPC1RAB9A | |
| SCHEMBL570366 | 0.68 | KMT2A (0.49) | GAAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL569395 | 0.66 | ALDH1A1 (0.38) | TDP1SMN1; SMN2KDM4EHSD17B10MEN1 | |
| SCHEMBL12181187 | 0.66 | KDM4E (0.81) | HDAC3HDAC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17511092 | 0.66 | RAB9A (0.70) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL15580191 | 0.65 | HDAC3 (0.76) | HDAC3HDAC1HDAC6NPC1RAB9A | |
| SCHEMBL6976547 | 0.64 | NPSR1 (0.64) | NPC1RAB9ASMN1; SMN2HPGDMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601208-A2 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY | Graffinity Pharmaceuticals GmbH (DE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017021-A2 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY | GRAFFINITY PHARMACEUTICALS GMBH (DE) | 2012-02-09 | — | — | WO | disclosed |