Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | RORB | Q92753 | 2/20 | 0.46 |
| ▸ | IL2 | P60568 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4724483 | 0.91 | PARP1 (0.59) | PARP1KIF11KDM4ECNR2RORC | |
| SCHEMBL16127491 | 0.81 | IKBKB (0.53) | CNR2AKR1C3AKR1C2IL2MAPT | |
| Trifluoroacetic Acid SCHEMBL31255312 | 0.79 | BCAT2 (0.46) | PARP1KDM4EMAPTCES2 | |
| SCHEMBL30272163 | 0.79 | RORB (0.66) | PARP1KIF11KDM4ECNR2RORC | |
| SCHEMBL4683411 | 0.79 | RORB (0.66) | PARP1KIF11KDM4ECNR2RORC | |
| SCHEMBL30411754 | 0.79 | GPR52 (0.46) | PARP1KIF11KDM4ECNR2AKR1C3 | |
| SCHEMBL352877 | 0.78 | PARP1 (0.50) | PARP1KIF11KDM4ECNR2AKR1C3 | |
| SCHEMBL3455274 | 0.76 | PLG (0.54) | PARP1KIF11KDM4ECNR2JAK2 | |
| SCHEMBL5964891 | 0.75 | PARP1 (0.56) | PARP1KIF11KDM4ERORCRORB | |
| SCHEMBL27922027 | 0.75 | AURKA (0.49) | PARP1KDM4EMAPTCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667721-A2 | COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS | Novartis AG (CH) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027973-A2 | COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS | NOVARTIS AG (CH) | 2005-03-31 | — | — | WO | disclosed |