Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27655996 | 0.96 | ALDH1A1 (0.40) | ALDH1A1TP53LMNAKMT2ANPSR1 | |
| SCHEMBL27655973 | 0.88 | CHRM1 (0.40) | ALDH1A1TP53LMNANPSR1CHRM3 | |
| SCHEMBL27681882 | 0.88 | ALDH1A1 (0.41) | ALDH1A1TP53LMNAKMT2ANPSR1 | |
| SCHEMBL3956862 | 0.87 | ALDH1A1 (0.41) | ALDH1A1KMT2APOLBHPGDSMN1; SMN2 | |
| SCHEMBL3954346 | 0.86 | SLC6A2 (0.47) | LMNANPSR1SLC6A2SLC6A3 | |
| SCHEMBL27661852 | 0.86 | SLC6A2 (0.47) | LMNANPSR1SLC6A2SLC6A3 | |
| SCHEMBL27661848 | 0.86 | SLC6A2 (0.47) | ALDH1A1TP53LMNAKMT2ANPSR1 | |
| SCHEMBL27681433 | 0.86 | SLC6A2 (0.47) | LMNANPSR1SLC6A2SLC6A3 | |
| SCHEMBL27655992 | 0.85 | LMNA (0.39) | ALDH1A1LMNAKMT2ANPSR1MEN1 | |
| SCHEMBL4260651 | 0.84 | MEN1 (0.40) | ALDH1A1LMNAKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972920-A | Arylalkyl piperazine derivatives for the treatment of conditions ameliorated by monoamine reuptake including vasomotor symptoms | WYETH CORP (US) | 2007-05-30 | — | — | CN | disclosed |
| CN-1894226-A | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use | WYETH CORP (US) | 2007-01-10 | — | — | CN | disclosed |
| CN-1894227-A | Phenylpiperazine cycloalkanol derivatives and methods of their use | WYETH CORP (US) | 2007-01-10 | — | — | CN | disclosed |
| EP-1673358-A1 | PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005037808-A1 | PHENYLPIPERAZINE CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |