Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177304 | 0.80 | ALDH1A1 (0.40) | CRBNKMT2AMEN1GAA | |
| SCHEMBL4293844 | 0.74 | MEN1 (0.59) | KMT2AMEN1MAPTGAAPABPC1 | |
| SCHEMBL8085348 | 0.73 | CRBN (0.38) | CRBNKMT2AMEN1MAPTGAA | |
| SCHEMBL7807801 | 0.70 | CRBN (0.40) | CRBNKMT2AMEN1MAPTGAA | |
| SCHEMBL9802754 | 0.70 | CRBN (0.46) | CRBNKMT2AMEN1MAPTGAA | |
| SCHEMBL516531 | 0.67 | CRBN (0.31) | CRBN | |
| SCHEMBL10668871 | 0.65 | OR51E2 (0.42) | CRBN | |
| SCHEMBL11765567 | 0.63 | MEN1 (0.32) | KMT2AMEN1MAPTGAAPABPC1 | |
| SCHEMBL14410044 | 0.60 | MAOA (0.40) | CRBNMAPTGAATDP1 | |
| SCHEMBL2491820 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655289-A1 | Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives | EMBL (DE) | 2006-05-10 | — | — | EP | disclosed |