Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 6/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphonic Acid SCHEMBL11044392 | 0.93 | ALDH1A1 (0.58) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| Phosphonic Acid SCHEMBL11040987 | 0.87 | ALDH1A1 (0.50) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| Phosphonic Acid SCHEMBL20723523 | 0.86 | ALDH1A1 (0.78) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| Phosphonic Acid SCHEMBL11042967 | 0.86 | ALDH1A1 (0.50) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| Phosphonic Acid SCHEMBL28608610 | 0.85 | ALDH1A1 (0.50) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| SCHEMBL4653062 | 0.84 | ALDH1A1 (0.65) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| Phosphonic Acid SCHEMBL9262594 | 0.84 | LMNA (0.54) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| Phosphonic Acid SCHEMBL11880909 | 0.84 | LMNA (0.54) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| Phosphonic Acid SCHEMBL28813732 | 0.84 | LMNA (0.54) | ALDH1A1CA2TDP1CYP3A4TSHR | |
| Phosphonic Acid SCHEMBL2401623 | 0.84 | LMNA (0.54) | ALDH1A1CA2TDP1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030206857-A1 | Produce radium-223 by loading a mother nuclide on generator column containing Ac-resin on an inorganic matrix, or comprising a step using AC-resin in a liquid/liquid extraction system. | ALGETA AS (NO) | 2003-11-06 | — | — | US | claimed |
| EP-1140212-B1 | THE USE OF RADIUM-223 TO TARGET CALCIFIED TISSUES FOR PAIN PALLIATION AND THERAPY OF BONE CANCER | ALGETA AS (NO) | 2006-06-28 | — | — | EP | disclosed |
| US-20030206857-A1 | Produce radium-223 by loading a mother nuclide on generator column containing Ac-resin on an inorganic matrix, or comprising a step using AC-resin in a liquid/liquid extraction system. | ALGETA AS (NO) | 2003-11-06 | — | — | US | disclosed |
| US-6635234-B1 | Administering bone seeking alpha-emitting radionuclide having half-life allowing deeper incorporation into matrix of bone surfaces before decay and radioactive decay products from its transformation do not translocalize significantly | ANTICANCER THERAPEUTIC INVENTIONS AS (NO) | 2003-10-21 | — | — | US | disclosed |