Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1511641 | 0.85 | PDE10A (0.50) | PDE10ASYKKCNH2CCR2PDK2 | |
| SCHEMBL2483932 | 0.80 | PDE10A (0.40) | PDE10AKCNH2CCR2PDK2CYP3A4 | |
| SCHEMBL13646228 | 0.78 | SIGMAR1 (0.39) | SIGMAR1SYKDRD2CCNT1CDK9 | |
| SCHEMBL2512346 | 0.78 | POLB (0.43) | PDE10A | |
| SCHEMBL1749680 | 0.76 | DRD2 (0.40) | SIGMAR1SYKDRD2HTR2CCCNT1 | |
| SCHEMBL652585 | 0.76 | DRD2 (0.56) | SIGMAR1SYKDRD2 | |
| SCHEMBL654668 | 0.75 | DRD2 (0.59) | SIGMAR1DRD2CHRNB2CHRNA4OPRD1 | |
| SCHEMBL25218643 | 0.75 | OPRM1 (0.40) | SIGMAR1HTR2CHTR3EHTR3BADRB1 | |
| SCHEMBL13646222 | 0.74 | SMO (0.46) | SIGMAR1SYKDRD2OPRD1 | |
| Hydrochloric Acid SCHEMBL9529474 | 0.73 | DRD2 (0.58) | SIGMAR1DRD2CHRNB2CHRNA4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673367-A1 | FUSED LACTAM COMPOUNDS | Pfizer, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005035523-A1 | FUSED LACTAM COMPOUNDS | PFIZER JAPAN INC. (JP) | 2005-04-21 | — | — | WO | disclosed |