Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222152 | 0.88 | ALDH1A1 (0.58) | NPC1TDP1OPRM1HTR2AHTR1A | |
| SCHEMBL5545640 | 0.87 | GRIN2B (0.52) | NPC1TDP1OPRM1HTR2AHTR1A | |
| SCHEMBL7512379 | 0.86 | GRIN2B (0.56) | NPC1OPRM1HTR2AHTR1ADRD4 | |
| SCHEMBL4681388 | 0.86 | OPRM1 (0.56) | NPC1OPRM1HTR2AHTR1ADRD4 | |
| SCHEMBL7357273 | 0.84 | OPRM1 (0.55) | NPC1OPRM1HTR2AHTR1ADRD4 | |
| SCHEMBL7357267 | 0.83 | OPRM1 (0.57) | NPC1OPRM1HTR2AHTR1ADRD4 | |
| SCHEMBL1000788 | 0.83 | MEN1 (0.71) | NPC1TDP1GRIN2BL3MBTL1SIGMAR1 | |
| SCHEMBL7424105 | 0.83 | MEN1 (0.71) | NPC1TDP1GRIN2BL3MBTL1SIGMAR1 | |
| SCHEMBL6510287 | 0.82 | L3MBTL1 (0.56) | NPC1OPRM1HTR2AHTR1ADRD4 | |
| SCHEMBL794423 | 0.81 | MEN1 (0.69) | NPC1TDP1HTR2AHTR1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680400-A2 | DERIVATIVES OF N-[ PHENYL(PYRROLIDINE-2-YL)METHYL]BENZAMIDE AND N-[ (AZEPAN-2-YL)PHENYLMETHYL]BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005037785-A2 | DERIVATIVES OF N-[PHENYL(PYRROLIDINE-2-YL)METHYL]BENZAMIDE AND N-[(AZEPAN-2-YL)PHENYLMETHYL]BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2005-04-28 | — | — | WO | disclosed |