Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 6/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.53 |
| ▸ | RELA | Q04206 | 6/20 | 0.53 |
| ▸ | TNKS | O95271 | 2/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3293396 | 0.75 | CYP1A2 (0.44) | ATMLMNASMN1; SMN2CYP1A2HTT | |
| SCHEMBL633303 | 0.74 | LMNA (0.55) | LMNASMN1; SMN2CYP1A2HTTALDH1A1 | |
| SCHEMBL6154117 | 0.74 | LMNA (0.55) | LMNASMN1; SMN2CYP1A2HTTALDH1A1 | |
| SCHEMBL633304 | 0.74 | LMNA (0.55) | LMNASMN1; SMN2CYP1A2HTTALDH1A1 | |
| SCHEMBL5697391 | 0.74 | SIGMAR1 (0.43) | NFKB1NFKB2RELAALDH1A1 | |
| SCHEMBL5697404 | 0.73 | CYP1A2 (0.45) | ATMLMNASMN1; SMN2CYP1A2HTT | |
| SCHEMBL28134908 | 0.71 | HTR2C (0.45) | LMNASMN1; SMN2CASP1ALDH1A1 | |
| SCHEMBL8731674 | 0.71 | LMNA (0.54) | LMNASMN1; SMN2CYP1A2HTTALDH1A1 | |
| SCHEMBL7735979 | 0.70 | LMNA (0.59) | LMNASMN1; SMN2CYP1A2HTTALDH1A1 | |
| SCHEMBL7735981 | 0.70 | LMNA (0.59) | LMNASMN1; SMN2CYP1A2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675842-A1 | DIHYDROBENZOFURANYL ALKANAMINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Wyeth (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005040146-A1 | DIHYDROBENZOFURANYL ALKANAMINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WYETH (US) | 2005-05-06 | — | — | WO | disclosed |