SCHEMBL5697459

SCHEMBL5697459

O=[N+]([O-])c1ccc(F)c(F)c1.O=[N+]([O-])c1ccc(N2CCCCC2)c(F)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.68
KMT2A Q03164 2/20 0.68
GAA P10253 1/20 0.64
LMNA P02545 3/20 0.61
SMN1; SMN2 Q16637 4/20 0.58
CYP1A2 P05177 2/20 0.56
CYP3A4 P08684 2/20 0.56
CYP2C9 P11712 2/20 0.56
CYP2C19 P33261 2/20 0.56
NPSR1 Q6W5P4 1/20 0.56
HPGD P15428 1/20 0.56
MEN1 O00255 1/20 0.56
SLC6A9 P48067 1/20 0.56
SLC6A5 Q9Y345 1/20 0.56
MAPT P10636 4/20 0.55
THRB P10828 1/20 0.55
HTT P42858 2/20 0.53
MITF O75030 1/20 0.53
HSP90AA1 P07900 1/20 0.53
CYP2D6 P10635 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1127011 0.95 ALDH1A1 (0.73) ALDH1A1KMT2AGAALMNASMN1; SMN2
SCHEMBL85672 0.95 ALDH1A1 (0.73) ALDH1A1KMT2AGAALMNASMN1; SMN2
SCHEMBL30928952 0.95 ALDH1A1 (0.73) ALDH1A1KMT2AGAALMNASMN1; SMN2
SCHEMBL4921368 0.94 ALDH1A1 (0.75) ALDH1A1KMT2AGAALMNASMN1; SMN2
SCHEMBL6687570 0.89 MAPT (0.69) ALDH1A1KMT2AGAALMNASMN1; SMN2
SCHEMBL14464189 0.88 ALDH1A1 (0.79) ALDH1A1KMT2AGAALMNASMN1; SMN2
SCHEMBL30843930 0.86 GAA (0.65) ALDH1A1KMT2AGAALMNASMN1; SMN2
SCHEMBL5240348 0.86 ALDH1A1 (0.64) ALDH1A1KMT2ALMNASMN1; SMN2CYP1A2
SCHEMBL18396735 0.84 ALDH1A1 (0.66) ALDH1A1KMT2AGAALMNASMN1; SMN2
SCHEMBL1640562 0.82 ALDH1A1 (0.60) ALDH1A1KMT2AGAALMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673342-A2 AMIDES THAT INHIBIT VANILLOID RECEPROT SUBTYPE 1 (VR1) RECEPTOR ABBOTT LABORATORIES (US) 2006-06-28 EP disclosed
WO-2005040121-A2 AMIDES THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR ABBOTT LABORATORIES (US) 2005-05-06 WO disclosed