Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PRKCI | P41743 | 1/20 | 0.54 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | AGXT | P21549 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12294066 | 0.90 | TSHR (0.55) | TSHRPRKCIACMSDBACE1AGXT | |
| SCHEMBL21973519 | 0.90 | TSHR (0.55) | TSHRPRKCIACMSDBACE1AGXT | |
| SCHEMBL249824 | 0.87 | PRKCI (0.70) | TSHRPRKCIACMSDAGXTCNR2 | |
| SCHEMBL30108284 | 0.87 | PRKCI (0.70) | TSHRPRKCIACMSDAGXTCNR2 | |
| SCHEMBL4191589 | 0.83 | PRKCI (0.72) | TSHRPRKCIACMSDAGXTCNR2 | |
| SCHEMBL23750160 | 0.82 | PRKCI (0.63) | TSHRPRKCIACMSDAGXTCNR2 | |
| SCHEMBL18297788 | 0.81 | PRKCI (0.76) | TSHRPRKCIACMSDAGXTCNR2 | |
| SCHEMBL18586418 | 0.80 | FFAR4 (0.50) | TSHRPRKCICNR2ALDH1A1GRIN2D | |
| SCHEMBL17954220 | 0.80 | RXRA (0.55) | TSHRPRKCIACMSDBACE1CNR2 | |
| SCHEMBL3786783 | 0.80 | MAOA (0.48) | TSHRPRKCIACMSDBACE1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546134-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | ELI LILLY AND COMPANY (US) | 2005-06-29 | — | — | EP | claimed |
| WO-2004014895-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | claimed |
| EP-1684746-A1 | USE OF 1-AZA-DIBENZO[e,h]|AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005049011-A1 | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-06-02 | — | — | WO | disclosed |