Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.69 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.69 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.69 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.69 |
| ▸ | ACMSD | Q8TDX5 | 4/20 | 0.50 |
| ▸ | HNF4A | P41235 | 2/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL569680 | 0.82 | POLB (0.63) | GRIN2DGRIN2AGRIN2BGRIN2CPOLB | |
| SCHEMBL569344 | 0.82 | GRIN2D (1.00) | GRIN2DGRIN2AGRIN2BGRIN2CACMSD | |
| SCHEMBL9250480 | 0.81 | GRIN2D (0.44) | GRIN2DGRIN2AGRIN2BGRIN2CPTPN1 | |
| SCHEMBL569239 | 0.78 | GRIN2A (0.49) | GRIN2DGRIN2AGRIN2BGRIN2CMCL1 | |
| SCHEMBL569383 | 0.71 | ACMSD (0.68) | GRIN2DGRIN2AGRIN2BGRIN2CACMSD | |
| SCHEMBL19880365 | 0.71 | ESR1 (0.36) | GRIN2DGRIN2AGRIN2BGRIN2CLCK | |
| SCHEMBL27999624 | 0.70 | PTPN1 (0.78) | GRIN2DGRIN2AGRIN2BGRIN2CACMSD | |
| SCHEMBL28596917 | 0.70 | ACMSD (0.63) | ACMSDHNF4ADHFRMCL1PTPN1 | |
| SCHEMBL31607059 | 0.70 | ACMSD (0.63) | GRIN2DGRIN2AGRIN2BGRIN2CACMSD | |
| SCHEMBL1250945 | 0.69 | ACMSD (0.68) | GRIN2DGRIN2AGRIN2BGRIN2CACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019106-A2 | POSITIVE AND NEGATIVE MODULATORS OF NMDA RECEPTORS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2012019106-A2 | POSITIVE AND NEGATIVE MODULATORS OF NMDA RECEPTORS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-02-09 | — | — | WO | disclosed |