SCHEMBL5701595

SCHEMBL5701595

CC[Si](CC)(CC)OC(CO[SiH3])(O[Si](CC)(CC)CC)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 2/20 0.32
MAPK1 P28482 1/20 0.31
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5701845 0.82 MAPK1 (0.33) KCNN4MAPK1ALDH1A1
SCHEMBL1225535 0.76 CES1 (0.40) KCNN4MAPK1ALDH1A1
SCHEMBL5701475 0.76
SCHEMBL5702112 0.75 KCNN4 (0.34) KCNN4MAPK1ALDH1A1TSHR
SCHEMBL22160046 0.74 KCNN4 (0.39) KCNN4MAPK1ALDH1A1TSHR
SCHEMBL5701579 0.71 MAPK1 (0.33) KCNN4MAPK1ALDH1A1
SCHEMBL705039 0.68 ESR1 (0.39) KCNN4MAPK1ALDH1A1
SCHEMBL704242 0.68 KCNN4 (0.38) KCNN4MAPK1ALDH1A1
SCHEMBL109031 0.67 TAAR1 (0.52) KCNN4MAPK1ALDH1A1
SCHEMBL705543 0.67 MAPK1 (0.44) KCNN4MAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1510520-B1 Preparation of branched siloxane SHINETSU CHEMICAL CO (JP) 2006-07-26 EP disclosed
US-6943264-B2 Preparation of branched siloxane SHIN-ETSU CHEMICAL, CO., LTD. (JP) 2005-09-13 US disclosed
US-20050049427-A1 Preparation of branched siloxane SHIN-ETSU CHEMICAL CO., LTD. (JP) 2005-03-03 US disclosed
EP-1510520-A1 Preparation of branched siloxane Shin-Etsu Chemical Co., Ltd. (JP) 2005-03-02 EP disclosed