Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22595837 | 0.81 | POLB (0.35) | NOS3NOS2NOS1DHFRGAA | |
| SCHEMBL9432009 | 0.80 | CD274 (0.38) | TAAR1GAAPOLBAPOBEC3AAPOBEC3G | |
| SCHEMBL11993969 | 0.78 | PIK3CA (0.41) | PIK3CAMAPTCASP1AURKATTK | |
| SCHEMBL9846287 | 0.78 | GAA (0.33) | TAAR1GAAPOLBAPOBEC3AAPOBEC3G | |
| SCHEMBL9432036 | 0.78 | GAA (0.36) | AURKBGAAPOLBAPOBEC3AAPOBEC3G | |
| SCHEMBL9432058 | 0.77 | TAAR1 (0.50) | TAAR1 | |
| SCHEMBL9272505 | 0.76 | PDE4A (0.40) | MAPTGAAPOLBGRM1 | |
| SCHEMBL215544 | 0.76 | PIK3CA (0.41) | PIK3CANOS3NOS2NOS1DHFR | |
| SCHEMBL38665916 | 0.76 | PIK3CA (0.41) | PIK3CANOS3NOS2NOS1DHFR | |
| SCHEMBL9267418 | 0.75 | ALDH1A1 (0.39) | GAAAPOBEC3AAPOBEC3GGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073637-B1 | 3-(AMINO- OR AMINOALKYL)PYRIDINONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF HIV RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2006-08-02 | — | — | EP | disclosed |
| US-6683079-B2 | REVERSE TRANSCRIPTASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2004-01-27 | — | — | US | disclosed |
| US-20030125340-A1 | Reverse transcriptase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENT. (FR) | 2003-07-03 | — | — | US | disclosed |
| US-6451822-B1 | 3-(Amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of HIV related diseases | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2002-09-17 | — | — | US | disclosed |
| EP-1073637-A1 | 3-(AMINO- OR AMINOALKYL)PYRIDINONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF HIV RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055676-A1 | 3-(AMINO- OR AMINOALKYL)PYRIDINONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF HIV RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1999-11-04 | — | — | WO | disclosed |
| US-5780472-A | ANTITUMOR AGENTS | SAMJIN PHARMACEUTICAZL CO., LTD. (KR) | 1998-07-14 | — | — | US | disclosed |
| EP-0749425-A1 | NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME | SAMJIN PHARM. CO., LTD. (KR) | 1996-12-27 | — | — | EP | disclosed |
| WO-1996021648-A1 | NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 1996-07-18 | — | — | WO | disclosed |
| US-5308854-A | 2-benzoxazolylalkyl substituted pyridin-2(1H)(thi)ones; AIDS | MERCK & CO., INC. (US) | 1994-05-03 | — | — | US | disclosed |
| EP-0462808-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125340-A1 | Reverse transcriptase inhibitors | QTRT1, RTF2, POLR1A | PIK3CA 2707/4885NOS3 2422/4885NOS2 4322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.