Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Azelaic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.55 |
| ▸ | DGKA | P23743 | 1/20 | 0.54 |
| ▸ | RARB | P10826 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PAM | P19021 | 2/20 | 0.50 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cetyl Palmitate SCHEMBL8430810 | 0.96 | TSHR (0.60) | TSHRTP53PLA2G4BDGKARARB | |
| Benzoic Acid SCHEMBL27584260 | 0.94 | TSHR (0.59) | TSHRTP53PLA2G4BDGKARARB | |
| Terephthalic Acid SCHEMBL28336967 | 0.94 | TP53 (0.63) | TSHRTP53PLA2G4BDGKARARB | |
| Isophthalic Acid SCHEMBL27618277 | 0.89 | DGKA (0.57) | TSHRTP53PLA2G4BDGKARARB | |
| Benzoic Acid SCHEMBL28235691 | 0.88 | TSHR (0.58) | TSHRTP53PLA2G4BRARBHTT | |
| Benzoic Acid SCHEMBL5830670 | 0.88 | TSHR (0.52) | TSHRTP53PLA2G4BDGKARARB | |
| Terephthalic Acid SCHEMBL17504571 | 0.87 | TP53 (0.65) | TSHRTP53PLA2G4BRARBHTT | |
| Octanoic Acid SCHEMBL6051069 | 0.87 | CES2 (0.64) | TSHR | |
| Decanoic Acid SCHEMBL10943211 | 0.87 | CES2 (0.64) | TSHR | |
| Heptanoate SCHEMBL5788520 | 0.87 | CES2 (0.64) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697461-A1 | POLYMER BLENDS WITH IMPROVED NOTCHED IMPACT STRENGTH | EASTMAN CHEMICAL COMPANY (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1697452-A1 | POLYESTER COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005063881-A1 | POLYMER BLENDS WITH IMPROVED NOTCHED IMPACT STRENGTH | EASTMAN CHEMICAL COMPANY (US) | 2005-07-14 | — | — | WO | disclosed |
| WO-2005063868-A1 | POLYESTER COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 2005-07-14 | — | — | WO | disclosed |