Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.47 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.47 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477773 | 0.87 | L3MBTL1 (0.43) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL5702073 | 0.84 | FFAR4 (0.50) | NPC1RAB9ASMN1; SMN2MAPTMRGPRX4 | |
| SCHEMBL6874912 | 0.83 | HPGD (0.51) | NPC1RAB9ASMN1; SMN2HPGDHTT | |
| SCHEMBL22325359 | 0.81 | FFAR1 (0.41) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL4286871 | 0.80 | POLB (0.50) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL21199371 | 0.79 | CCNB2 (0.43) | NPC1RAB9ASMN1; SMN2MAPTHTR1A | |
| SCHEMBL10172543 | 0.79 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL22469829 | 0.78 | MRGPRX4 (0.71) | MRGPRX4 | |
| SCHEMBL27618166 | 0.78 | ALDH1A1 (0.48) | SMN1; SMN2HPGDMAPTHTTL3MBTL1 | |
| SCHEMBL20445938 | 0.77 | MAPT (0.42) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673366-A1 | 1-\"2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL]-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS | Pfizer, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005035522-A1 | 1-‘2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL!-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS | PFIZER JAPAN, INC. (JP) | 2005-04-21 | — | — | WO | disclosed |