Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5703348 | 0.81 | KDM5B (0.38) | DGAT1SOAT1CCNE2CCNE1CDK2 | |
| SCHEMBL5703309 | 0.81 | ADORA2A (0.37) | DGAT1SOAT1SLC9A5 | |
| SCHEMBL5703442 | 0.81 | USP8 (0.43) | — | |
| SCHEMBL5703301 | 0.80 | DGAT1 (0.34) | DGAT1SOAT1CDC7 | |
| SCHEMBL5703412 | 0.79 | IKBKB (0.35) | CDC7GRM5 | |
| SCHEMBL5703293 | 0.74 | PLAU (0.40) | PLAUKMT2A | |
| SCHEMBL5703183 | 0.71 | LDHA (0.37) | — | |
| SCHEMBL5703212 | 0.70 | DHODH (0.36) | — | |
| SCHEMBL5703327 | 0.70 | SLC9A1 (0.35) | CCNE1CDK2CDC7 | |
| SCHEMBL4584131 | 0.68 | ADORA2A (0.46) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678160-A1 | PYRAZINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | Astellas Pharma Inc. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040151-A1 | PYRAZINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | ASTELLAS PHARMA INC. (JP) | 2005-05-06 | — | — | WO | disclosed |