SCHEMBL5703446

SCHEMBL5703446

Cc1ccccc1N1C(=O)C(=O)c2ccccc21

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 5/20 0.61
ALDH1A1 P00352 3/20 0.61
BCHE P06276 2/20 0.61
NPSR1 Q6W5P4 2/20 0.61
CES2 O00748 1/20 0.61
GAA P10253 1/20 0.61
KMT2A Q03164 5/20 0.57
MEN1 O00255 4/20 0.57
MGLL Q99685 1/20 0.55
TTR P02766 1/20 0.55
CASP3 P42574 1/20 0.54
CASP6 P55212 1/20 0.54
SENP8 Q96LD8 1/20 0.54
SENP7 Q9BQF6 1/20 0.54
SENP6 Q9GZR1 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
MAPT P10636 2/20 0.50
TGM2 P21980 2/20 0.49
LMNA P02545 2/20 0.48
NR1H2 P55055 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29506684 1.00 CES1 (0.61) CES1ALDH1A1BCHENPSR1CES2
SCHEMBL9734396 0.87 CES1 (0.56) CES1ALDH1A1BCHENPSR1CES2
SCHEMBL4208512 0.84 AGTR1 (0.57) CES1ALDH1A1BCHENPSR1CES2
SCHEMBL30758615 0.82 KMT2A (0.73) ALDH1A1NPSR1GAAKMT2AMEN1
SCHEMBL29379598 0.82 KMT2A (0.73) ALDH1A1NPSR1GAAKMT2AMEN1
SCHEMBL2550815 0.82 KMT2A (0.73) ALDH1A1NPSR1GAAKMT2AMEN1
SCHEMBL30777592 0.82 KMT2A (0.73) ALDH1A1NPSR1GAAKMT2AMEN1
SCHEMBL11561791 0.79 CES1 (0.50) CES1ALDH1A1BCHENPSR1CES2
SCHEMBL20721761 0.78 CES1 (0.73) CES1ALDH1A1BCHENPSR1CES2
SCHEMBL29506688 0.78 CES1 (0.73) CES1ALDH1A1BCHENPSR1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108430970-B Bisphenol compound and aromatic polycarbonate 本州化学工业株式会社 2022-03-11 CN disclosed
US-10759755-B2 Bisphenol compound and aromatic polycarbonate HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) 2020-09-01 US disclosed
US-20190047954-A1 BISPHENOL COMPOUND AND AROMATIC POLYCARBONATE HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) 2019-02-14 US disclosed
EP-0709466-B1 Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences GEN PROBE INC (US) 2006-09-27 EP disclosed
US-5840873-A PLURALITY OF DIFFERENT OLIGONUCLEOTIDE PROBES EACH COUPLED TO DIFFERENT CHEMILUMINESCENT LABEL GEN-PROBE INCORPORATED (US) 1998-11-24 US disclosed
US-5827656-A UTILIZING OLIGONUCLEOTIDE HYBRIDIZATION PROBE COUPLED TO DIFFERENT CHEMILUMINESCENT ACRIDINIUM ESTER LABELS WHICH HYBRIDIZES TO NUCLEIC ACID ANALYTES GEN-PROBE INCORPORATED (US) 1998-10-27 US disclosed
US-5756709-A PLURALITY OF DIFFERENT OLIGONUCLEOTIDE HYBRIDIZATION PROBES EACH COUPLED TO DIFFERENT CHEMILUMINESCENT LABELS GEN-PROBE INCORPORATED (US) 1998-05-26 US disclosed
US-5658737-A KIT CONTAINING OLIGONUCLEOTIDE HYBRIDIZATION ASSAY PROBES ABLE TO HYBRIDIZE TO DIFFERENT NUCLEIC ACID TARGET ANALYTES, EACH COUPLED WITH DIFFERENT CHEMILUMINESCENT LABEL GEN-PROBE INCORPORATED (US) 1997-08-19 US disclosed
WO-1996013612-A2 COMPOSITIONS AND METHODS FOR THE SIMULTANEOUS DETECTION AND QUANTIFICATION OF MULTIPLE SPECIFIC NUCLEIC ACID SEQUENCES GEN-PROBE INCORPORATED (US) 1996-05-09 WO disclosed
EP-0709466-A2 Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences GEN-PROBE INCORPORATED (US) 1996-05-01 EP disclosed
EP-0369344-B1 N-arylation of isatins ABBOTT LAB (US) 1994-04-06 EP disclosed
US-5151518-A N-arylation of isatins ABBOTT LABORATORIES (US) 1992-09-29 US disclosed
EP-0369344-A1 N-arylation of isatins ABBOTT LABORATORIES (US) 1990-05-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10759755-B2 Bisphenol compound and aromatic polycarbonate PAH, INCENP, BMP2 CES1 3539/4885ALDH1A1 2603/4885BCHE 3464/4885
US-20190047954-A1 BISPHENOL COMPOUND AND AROMATIC POLYCARBONATE PAH, INCENP, BMP2 CES1 3539/4885ALDH1A1 2603/4885BCHE 3464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.