⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27611891 | 0.97 | — | — | |
| SCHEMBL20351211 | 0.93 | ALDH1A1 (0.48) | — | |
| Acetic Acid SCHEMBL12987216 | 0.93 | ALDH1A1 (0.48) | — | |
| Acetonitrile SCHEMBL28822117 | 0.89 | ALDH1A1 (0.44) | — | |
| SCHEMBL698125 | 0.85 | — | — | |
| SCHEMBL22969100 | 0.83 | ALDH1A1 (0.48) | — | |
| SCHEMBL1044001 | 0.83 | DGKA (0.65) | — | |
| Chloromethane SCHEMBL8775781 | 0.83 | DGKA (0.54) | — | |
| SCHEMBL4232985 | 0.83 | ADRA2A (0.42) | — | |
| Methylene Chloride SCHEMBL7065274 | 0.82 | ALDH1A1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 839 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903979-B1 | NOVEL COMPOUNDS, THEIR PREPARATION AND THEIR USES | INHIBIKASE THERAPEUTICS INC (US) | 2020-08-19 | — | — | EP | claimed |
| CN-111423362-A | Preparation method of two high-purity clevidipine butyrate impurities | 山东省药学科学院 | 2020-07-17 | — | — | CN | claimed |
| CN-109608436-A | Substituted Methylformyl reagent and the method for improving compound physical chemistry and/or pharmacokinetic property using the reagent | 斯法尔制药私人有限公司 | 2019-04-12 | — | — | CN | claimed |
| CN-105198797-B | The purification process of butyrate clevidipine | 华仁药业股份有限公司 | 2017-12-08 | — | — | CN | claimed |
| CN-104833670-B | A kind of method of real-time of butyrate clevidipine bulk drug building-up process | 中国人民解放军第二军医大学 | 2017-08-01 | — | — | CN | claimed |
| US-9487500-B2 | Compounds and compositions thereof | INHIBIKASE THERAPEUTICS, INC. (US) | 2016-11-08 | — | — | US | claimed |
| CN-105646493-A | Compound for preventing and treating organ damage, preparation method and applications thereof | 李玉明 | 2016-06-08 | — | — | CN | claimed |
| US-9359376-B2 | Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds | SPHAERA PHARMA PTE. LTD (SG) | 2016-06-07 | — | — | US | claimed |
| CN-105198797-A | Purification method of clevidipine butyrate | HUAREN PHARMACEUTICAL CO LTD | 2015-12-30 | — | — | CN | claimed |
| CN-104833670-A | Real-time monitoring method for clevidipine butyrate crude drug synthesis process | UNIV PLA 2ND MILITARY MEDICAL | 2015-08-12 | — | — | CN | claimed |
| WO-2012137225-A1 | SUBSTITUTED METHYLFORMYL REAGENTS AND METHOD OF USING SAME TO MODIFY PHYSICOCHEMICAL AND/OR PHARMACOKINETIC PROPERTIES OF COMPOUNDS | SPHAERA PHARMA PVT. LTD (IN) | 2012-10-11 | — | — | WO | claimed |
| CN-102516741-A | Method of reducing the styrene content of a poly(arylene ether)/polystyrene blend, and articles comprising the resulting thermoplastic resin | SABIC INNOVATIVE PLASTICS IP | 2012-06-27 | — | — | CN | claimed |
| WO-2011130852-A1 | PREPARATION OF INTERMEDIATES FOR THE SYNTHESIS OF DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS | ALPHORA RESEARCH INC. (CA) | 2011-10-27 | — | — | WO | claimed |
| WO-2011127599-A1 | PREPARATION OF CLEVIDIPINE BUTYRATE | ALPHORA RESEARCH INC. (CA) | 2011-10-20 | — | — | WO | claimed |
| CN-101287799-A | Method of reducing the styrene content of poly (arylene ether)/polystyrene blends, and articles comprising the resulting thermoplastic resins | GEN ELECTRIC (US) | 2008-10-15 | — | — | CN | claimed |
| US-20050240025-A1 | Method for producing imidazolium salts | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2005-10-27 | — | — | US | claimed |
| EP-1133473-B1 | NEW MANUFACTURING PROCESS | ASTRAZENECA AB (SE) | 2003-04-09 | — | — | EP | claimed |
| US-6350877-B1 | MANUFACTURE OF CLEVIDIPINE BY SALT FORMATION ESTERIFICATION | ASTRAZENECA AB (SE) | 2002-02-26 | — | — | US | claimed |
| EP-1133473-A1 | NEW MANUFACTURING PROCESS | AstraZeneca AB (SE) | 2001-09-19 | — | — | EP | claimed |
| WO-2000031035-A1 | NEW MANUFACTURING PROCESS | ASTRAZENECA AB (SE) | 2000-06-02 | — | — | WO | claimed |