SCHEMBL5704372

SCHEMBL5704372

CC(=O)c1c(Cl)c(F)c(Cl)c(F)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
THRB P10828 1/20 0.32
CYP3A4 P08684 1/20 0.32
HPGD P15428 1/20 0.32
LMNA P02545 1/20 0.31
HTT P42858 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9635042 0.90 CES2 (0.43) CES2CES1MEN1KMT2ATHRB
SCHEMBL8528421 0.90 CES2 (0.46) CES2CES1MEN1KMT2ATHRB
SCHEMBL29150329 0.77 CES2 (0.42) CES2CES1MEN1KMT2ATHRB
SCHEMBL29042640 0.74 CYP3A4 (0.39) CES2CES1MEN1KMT2ATHRB
SCHEMBL31727216 0.72 THRB (0.37) CES2CES1MEN1KMT2ATHRB
SCHEMBL19360080 0.71 CES2 (0.42) CES2CES1MEN1KMT2ATHRB
SCHEMBL823811 0.71 CES2 (0.42) CES2CES1MEN1KMT2ATHRB
SCHEMBL124392 0.71 CES2 (0.42) CES2CES1MEN1KMT2ATHRB
SCHEMBL10406919 0.70 CES2 (0.42) CES2CES1HTTSMN1; SMN2
SCHEMBL9633943 0.70 CYP3A4 (0.39) MEN1KMT2ATHRBCYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1319656-B1 A NEW PROCESS FOR PREPARING A QUINOLONE-CARBOXYLIC ACID LYNCHEM CO LTD (CN) 2006-08-23 EP disclosed
US-6699992-B2 REACTING M-FLUOROACETOPHENONE COMPOUND WITH ALKYL CARBONATE; REACTING ESTER OBTAINED WITH ALKYL ORTHOFORMATE AND AMINE; CYCLIZATION IN BASE LYNCHEM CO., LTD. (CN) 2004-03-02 US disclosed
US-20030166936-A1 Process for preparing a quinolone-carboxylic acid LYNCHEM CO., LTD. (CN) 2003-09-04 US disclosed
EP-1319656-A1 A NEW PROCESS FOR PREPARING A QUINOLONE-CARBOXYLIC ACID Lynchem Co., Ltd. (CN) 2003-06-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030166936-A1 Process for preparing a quinolone-carboxylic acid CYP4B1, QPCT, NQO2 CES2 1150/4885CES1 313/4885MEN1 2130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.