SCHEMBL5705237

SCHEMBL5705237

O=C(Cl)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)F

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.38
KDM4E B2RXH2 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
HTT P42858 1/20 0.37
THRB P10828 1/20 0.34
USP2 O75604 1/20 0.34
MAPT P10636 1/20 0.34
GAA P10253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10617895 1.00 TSHR (0.38) TSHRKDM4ETDP1L3MBTL1HTT
SCHEMBL7729495 1.00 TSHR (0.38) TSHRKDM4ETDP1L3MBTL1HTT
SCHEMBL3423677 1.00 TSHR (0.38) TSHRKDM4ETDP1L3MBTL1HTT
SCHEMBL2796672 0.91 KDM4E (0.40) TSHRKDM4ETDP1
SCHEMBL7733766 0.90 THRB (0.45) TSHRKDM4ETDP1L3MBTL1HTT
SCHEMBL8103486 0.85 THRB (0.41) TSHRKDM4ETDP1L3MBTL1HTT
SCHEMBL28464094 0.83 THRB (0.32) THRB
SCHEMBL10831355 0.83 THRB (0.32) THRB
SCHEMBL28461375 0.83 THRB (0.32) THRB
SCHEMBL11904370 0.83 THRB (0.46) THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0893740-B1 Electrophotographic photoreceptor and a production method of the same KONICA CORP (JP) 2006-10-18 EP disclosed
US-6099998-A BINDER COMPRISES A CROSSLINKED RESIN HAVING RECURRING UNIT OF A UNSATURATED MONOMER CONTAINING SILICON OR FLUORINE IN ITS SIDE CHAIN AND A PORTION HAVING AN AROMATIC GROUP IN MAIN OR SIDE CHAIN AND A PORTION HAVING HYDROXY OR AMINO GROUP KONICA CORPORATION (JP) 2000-08-08 US disclosed
US-5942387-A Combinatorial process for preparing substituted thiophene libraries ELI LILLY AND COMPANY (US) 1999-08-24 US disclosed
EP-0893740-A2 Electrophotographic photoreceptor and a production method of the same KONICA CORPORATION (JP) 1999-01-27 EP disclosed
EP-0825164-A2 Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides ELI LILLY AND COMPANY (US) 1998-02-25 EP disclosed
US-5057623-A Magnetic coating material dispersants MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 1991-10-15 US disclosed
EP-0363987-A2 Organic fluorine compound MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 1990-04-18 EP disclosed