Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31324002 | 0.93 | ALDH1A1 (0.47) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL4086467 | 0.90 | LMNA (0.57) | KDM4EHSD17B10ALDH1A1HPGDKMT2A | |
| SCHEMBL4768364 | 0.83 | HSD17B10 (0.75) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL30306133 | 0.83 | HSD17B10 (0.75) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL27763662 | 0.82 | KDM4E (0.60) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL3973297 | 0.80 | KDM4E (0.67) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL31310732 | 0.79 | HPGD (0.45) | KDM4EHSD17B10ALDH1A1HPGDKMT2A | |
| SCHEMBL29841020 | 0.77 | MAPT (0.45) | ALDH1A1TSHRKMT2AMEN1LMNA | |
| SCHEMBL17024931 | 0.77 | MAPT (0.45) | ALDH1A1TSHRKMT2AMEN1LMNA | |
| SCHEMBL28697181 | 0.76 | LMNA (0.46) | KDM4EALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628988-B1 | NOVEL 14 AND 15 MEMBERED-RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2006-10-04 | — | — | EP | disclosed |