Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747792 | 0.89 | SMN1; SMN2 (0.44) | LMNAMAPTALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL28702756 | 0.86 | LMNA (0.48) | LMNAMAPTALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL28682374 | 0.85 | GPR119 (0.45) | LMNAMAPTALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL30768232 | 0.84 | SMN1; SMN2 (0.41) | LMNAMAPTALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL28699335 | 0.84 | SMN1; SMN2 (0.41) | LMNAMAPTALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL28932211 | 0.84 | LMNA (0.48) | LMNAMAPTALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL28677826 | 0.78 | MAPT (0.48) | LMNAMAPTALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL30768240 | 0.77 | PARP1 (0.42) | GPR119 | |
| SCHEMBL31324002 | 0.76 | ALDH1A1 (0.47) | LMNAMAPTALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL5706238 | 0.76 | KDM4E (0.53) | LMNAMAPTALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113874354-B | Pyridone derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-113874354-A | Pyridone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-12-31 | — | — | CN | disclosed |