Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518509 | 0.81 | L3MBTL1 (0.43) | ALDH1A1SMN1; SMN2L3MBTL1TDP1MAP2K1 | |
| SCHEMBL4504422 | 0.81 | TAAR1 (0.36) | ALDH1A1SMN1; SMN2AKR1B1TAAR1L3MBTL1 | |
| SCHEMBL4513880 | 0.79 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2AKR1B1TAAR1L3MBTL1 | |
| SCHEMBL4517422 | 0.78 | AKR1B1 (0.40) | ALDH1A1SMN1; SMN2AKR1B1MAP2K1HPGD | |
| SCHEMBL2006540 | 0.71 | AKR1B1 (0.43) | AKR1B1MAP2K1MAP2K2 | |
| SCHEMBL257063 | 0.70 | AKR1B1 (0.35) | AKR1B1MAP2K1MAP2K2 | |
| SCHEMBL27855541 | 0.69 | AKR1B1 (0.36) | AKR1B1MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL2403273 | 0.69 | L3MBTL1 (0.40) | ALDH1A1SMN1; SMN2L3MBTL1LMNAHPGD | |
| SCHEMBL14223949 | 0.68 | MCL1 (0.44) | ALDH1A1SMN1; SMN2L3MBTL1TDP1KDM4E | |
| SCHEMBL2129344 | 0.67 | ALDH1A1 (0.42) | ALDH1A1AKR1B1LMNAMAP2K1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696899-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058301-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2005-06-30 | — | — | WO | disclosed |