Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 10/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513887 | 0.81 | PTGES (0.44) | PTGESCXCR4MAP4K4PRMT5WDR77 | |
| SCHEMBL5706352 | 0.78 | HAO1 (0.37) | PTGESKMT2AHAO1ACACB | |
| SCHEMBL5706323 | 0.77 | PRMT5 (0.39) | CXCR4PRMT5WDR77NPY5RMEN1 | |
| SCHEMBL15587410 | 0.73 | CXCR4 (0.65) | CXCR4MAP4K4PRMT5WDR77MEN1 | |
| SCHEMBL4516752 | 0.72 | PTGES (0.48) | PTGESCXCR4ACACB | |
| SCHEMBL4516755 | 0.72 | PTGES (0.48) | PTGESCXCR4ACACB | |
| SCHEMBL4521335 | 0.72 | PTGES (0.48) | PTGESCXCR4ACACB | |
| SCHEMBL5706343 | 0.71 | DPP4 (0.46) | PTGES | |
| SCHEMBL4519671 | 0.71 | PTGES (0.45) | PTGESCXCR4ACACB | |
| SCHEMBL4523871 | 0.71 | FFAR1 (0.54) | PTGESCXCR4ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696899-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058301-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2005-06-30 | — | — | WO | disclosed |